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RuCl 3 / PPh 3 ‐ Catalyzed Direct Conversion of Isoxazol‐5‐ones to 2,3‐Disubstituted Pyridines
Author(s) -
Fernandes Alessandra A. G.,
Stivanin Mateus L.,
Jurberg Igor D.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900761
Subject(s) - catalysis , chemistry , acrolein , combinatorial chemistry , order (exchange) , medicinal chemistry , stereochemistry , organic chemistry , business , finance
A novel catalytic system employing RuCl 3 / PPh 3 is described for the preparation of 2,3‐disubstituted pyridines starting from 3,4‐disubstituted isoxazol‐5‐ones and acrolein. Mechanistic studies involving 31 P NMR, HRMS analyses and control experiments have been performed in order to support key events and intermediates proposed for this transformation.

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