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A Facile Direct Synthesis of 3‐Methyleneisoindolin‐1‐ones by Annulation of Methyl 2‐Acylbenzoates with Amines
Author(s) -
Dai XingJie,
Liu Min,
Zhang JiaYan,
Xu XiaoYing,
Yuan WeiCheng,
Zhang XiaoMei
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900759
Subject(s) - annulation , ammonium acetate , chemistry , ammonium , organic chemistry , combinatorial chemistry , catalysis , high performance liquid chromatography
A wide variety of 3‐methyleneisoindolin‐1‐ones have been prepared by annulation of methyl 2‐acylbenzoates with amines or ammonium acetate. The reactions proceeded smoothly to afford the desired products in up to quantitative yields.