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Gentamicin Loaded PLGA based Biodegradable Material for Controlled Drug Delivery
Author(s) -
Vijayakrishna Kari,
Patil Shrikant,
Shaji Leyana K,
Panicker Rakesh R
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900737
Subject(s) - plga , ultimate tensile strength , drug delivery , drug , materials science , controlled release , biomedical engineering , chemistry , pharmacology , composite material , nanotechnology , nanoparticle , medicine
In wound care there is room for delivering antibiotic drug at wound site to avoid or control the infections. This current work is about preparation and evaluation of poly(lactic‐ co ‐glycolic acid) (PLGA) and poly(caprolactone) (PCL) based, gentamicin (GE) loaded biodegradable material to get optimum drug at site for antibacterial action. Drug release, degradation behaviour and tensile properties of prepared bio‐material are studied up to 42 days. Drug release in in‐vitro release testing (IVRT) was studied by UV absorbance of receptor solution. Physical characteristics such as molecular weight, tensile strength and morphology of bio‐material are carried out as a function of time during IVRT studies. The employed bio‐material releases 3.4 μg/g/h drug with a steady decrease in tensile strength and PLGA molecular weight. In this manuscript it is demonstrate that PLGA and PCL based bio‐material will release the loaded drug in controlled manner with simultaneous degradation.