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DABCO Catalyzed Synthesis of β‐Hydroxy Ketones Derived from α‐Methyl Ketones and Ninhydrin under Microwave Irradiations
Author(s) -
Verma Pratibha,
Mishra Ankush,
Chauhan Swati,
Singh Sundaram,
Srivastava Vandana
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900720
Subject(s) - dabco , ninhydrin , ketone , chemistry , catalysis , substrate (aquarium) , octane , microwave , reaction conditions , solvent , combinatorial chemistry , organic chemistry , biochemistry , oceanography , physics , amino acid , quantum mechanics , geology
Microwave induced an efficient, green and rapid protocol for the synthesis of 2‐substituted‐2‐hydroxyindan‐1,3‐dione derivatives from the reaction of ninhydrin and ketone by using inexpensive 1,4‐diazabicyclo[2.2.2]octane (DABCO) organocatalyst in water has been developed. Mild reaction conditions, shorter reaction time, metal‐free approach, water as a green solvent, scalability and broad substrate scope are the salient features of this protocol.