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Synthesis and Evaluation of Enalapril‐Loaded PVA/PMC Modified Magnetic Nanoparticles as a Novel Efficient Nano‐Carrier
Author(s) -
Shahverdi Negin,
Heydarinasab Amir,
Panahi Homayon Ahmad,
Moniri Elham
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900697
Subject(s) - freundlich equation , thermogravimetric analysis , adsorption , magnetic nanoparticles , langmuir , nanoparticle , materials science , nuclear chemistry , chemical engineering , polyvinyl alcohol , enalapril , scanning electron microscope , polymer , chemistry , chromatography , organic chemistry , nanotechnology , composite material , angiotensin converting enzyme , medicine , radiology , blood pressure , engineering
In the present study, the development of new Enalapril‐loaded adsorbent and evaluation of drug release was studied in vitro. Initially, Fe 3 O 4 magnetic nanoparticles were synthesized via co‐precipitation method. Then, the mixture of polymers was deposited on the surface of the magnetic nanoparticles via radical polymerization in order to enhance the adsorption capacity of nanoparticles with biocompatible poly methylcellulose modified with polyvinyl alcohol. The equilibrium adsorption data magnetite nano‐sorbent were analyzed using Langmuir, Freundlich, and Temkin. The drug‐release study showed that 80% of Enalapril released in the simulated gastrointestinal environment for 18 hours. The samples and products analyzed by FTIR, elemental analysis, thermal gravimetric analysis (TGA) and scanning electron microscopy (SEM). Adsorption parameters such as pH, temperature and contact time were optimized, and Langmuir, Freundlich and Temkin's isotherms were studied for the drug adsorption mechanism. The release process of Enalapril studied in the simulated human digestive environment. The release profile of Enalapril has a very steep slope for 30 minutes in the simulated human gastric.