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Catalyst free Synthesis of Highly Functionalized Indolizines from In Situ Generated Pyridinium Ylides via One‐Pot Multicomponent Reaction
Author(s) -
Ramesh Vediyappan,
Devi Natarajan Savitha,
Velusamy Marappan,
Shanmugam Sivakumar
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900665
Subject(s) - indolizine , pyridinium , catalysis , chemistry , yield (engineering) , domino , cascade reaction , combinatorial chemistry , one pot synthesis , ring (chemistry) , in situ , organic chemistry , materials science , metallurgy
A base‐promoted one‐pot three‐component domino reaction of in situ generated pyridinium ylides with α ‐oxoketene dithioacetals (AKDTAs) lead to synthesis of indolizine derivatives. In this one‐pot transformation, three new bonds and one new ring was efficiently formed in one sequence. The current method provides a simple, convenient route for the synthesis of biologically important indolizine derivatives without using any catalyst in good yield. The synthesized compound 4 g was confirmed by single crystal X‐ray analysis.