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Iron‐Catalyzed Regioselective C5‐H Benzylation of 8‐Aminoquinolines with Benzylic Acetates
Author(s) -
Niu TianJing,
Xu JinDi,
Ren BaoZeng,
Liu JingHui,
Hu GuoQin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900664
Subject(s) - regioselectivity , quinoline , catalysis , chemistry , combinatorial chemistry , organic chemistry , compatibility (geochemistry) , materials science , composite material
Abstract A Fe‐catalyzed C5‐H benzylation reaction of 8‐amidoquinoline amides has been developed by employing cheap, abundant benzylic acetates as benzyl sources. This method showcases excellent functional group compatibility and is applicable for gram‐scale synthesis or late‐stage diversification. Thus it provides an easy access to the corresponding C5‐benzylated quinoline derivatives.