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Meglumine Promoted Strategy: Environmentally Benign Protocol towards the Synthesis of Polysubstituted 2‐Aminopyrroles in Aqueous Condition
Author(s) -
Yadav Vijay B.,
Yadav Neetu,
Rai Pragati,
Ansari Mohd Danish,
Kumar Akhilesh,
Verma Ankit,
Siddiqui I. R.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900490
Subject(s) - malononitrile , glyoxal , reusability , chemistry , combinatorial chemistry , catalysis , meglumine , protocol (science) , organic chemistry , computer science , medicine , software , magnetic resonance imaging , radiology , programming language , alternative medicine , pathology
A facile and highly efficient protocol for the one‐pot, four‐component synthesis of polysubstituted 2‐aminopyrroles by using glyoxal monohydrate derivatives, anilines, coumarin derivatives, and malononitrile has been developed. Meglumine used as an inexpensive, biodegradable and reusable catalyst. Simplicity, green solvent, easy work‐up process, cost effective and reusability of the promoter are the main advantages of reported methodology.