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A Straightforward Synthesis of Tribromomethyl Carbinols from Aldehydes and Bromoform with Potassium Hydroxide as the Catalyst
Author(s) -
Hasimujiang Balati,
Cheng Zhao,
Wusiman Abudureheman,
Yang Ying,
Abudu Rexit Abulikemu
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900356
Subject(s) - bromoform , catalysis , potassium hydroxide , yield (engineering) , raw material , chemistry , organic chemistry , potassium , aldehyde , hydroxide , materials science , chloroform , metallurgy
KOH was used as the catalyst for an efficient synthesis of tribromoethyl carbinols from aldehydes and bromoform. The new synthesis method has many advantages, such as the low price of the raw materials and catalyst, the wide range of substrates such as, aromatic, aliphatic and heterocyclic aldehydes. It's worth mentioning that the reaction could be scaled up to grams in excellent yield (99%), in the presence of 10 mol% KOH.