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An Efficient and Eco‐Friendly One‐Pot Synthesis of Pyrazolopyridines Mediated by Choline Chloride/Urea Eutectic Mixture
Author(s) -
Vanegas Sebastián,
Rodríguez Daniel,
OchoaPuentes Cristian
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900314
Subject(s) - choline chloride , eutectic system , urea , chemistry , ammonium chloride , catalysis , chloride , choline , organic chemistry , ammonium acetate , deep eutectic solvent , ammonia , high performance liquid chromatography , biochemistry , alloy
In this contribution several choline chloride‐based deep eutectic solvents were evaluated as novel reaction media for the multicomponent one‐pot synthesis of pyrazolopyridine derivatives. It was found that the reaction between hydrazines, ethyl acetoacetate, ammonium acetate and aldehydes or ketones is efficiently catalyzed by the eutectic mixture choline chloride/urea yielding a wide variety of tetrahydrodipyrazolopyridine derivatives in good to excellent yields. In addition, the low melting mixture was reused in four cycles without observing a detrimental catalytic activity.