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N ‐Acyloxyphthalimide as Multitasking Directing Group for Sequential C‐H Functionalization
Author(s) -
Sun Huan,
Jiang Yue,
Chen XiaoWei,
Zhou Yi−Bo,
Feng Tao,
Huang Rong,
Zheng Yongsheng,
Li ZhengHui,
Liu JiKai
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900201
Subject(s) - surface modification , isocoumarin , human multitasking , annulation , group (periodic table) , reagent , combinatorial chemistry , nucleophile , chemistry , block (permutation group theory) , organic chemistry , mathematics , biology , catalysis , geometry , neuroscience
Abstract N ‐Acyloxyphthalimide has been demonstrated as a multitasking directing group considering its easy accessibility, multiple reactive sites, and multifarious transformations available to generate valuable structural diversified scaffolds. Polysubstituted heterocycles, such as isocoumarin, isoquinolone, and its second annulation products, could be obtained from N ‐acyloxyphthalimide and alkynes through a one‐pot reaction in the presence of nucleophilic reagents. Additionally, the ester group possessed on the resulting heterocycles could serve as a new building block to direct further functionalization.