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A Phenyl Thioether‐Based Probe: Zn 2+ Ion Sensor, Structure Determination and Live Cell Imaging †
Author(s) -
Dey Sunanda,
Maity Suvendu,
Dasmahapatra Ananya,
Chattopadhyay Debprasad,
Sinha Chittaranjan
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900194
Subject(s) - thioether , crystal structure , ion , fluorescence , detection limit , crystallography , chemistry , metal ions in aqueous solution , hepes , analytical chemistry (journal) , nuclear chemistry , stereochemistry , physics , chromatography , biochemistry , organic chemistry , quantum mechanics
3,3′‐((1Z,1′Z)‐(((Propane‐1,3‐diylbis(sulfanediyl))bis(2,1‐phenylene))bis(azanyyldiene))bis(methanylylidene))bis(2‐hydroxy‐5‐methylbenzaldehyde) ( H 2 ‐SAP) , characterized by different spectroscopic data, exhibits yellow emission (λ em , 560 nm) when binds with Zn 2+ in H 2 O‐MeOH (1:9 v/v, HEPES buffer, pH 7.4) in a mixture of seventeen biologically important other metal ions. The limit of detection (LOD) is 9.0 nM which is far below the World Health Organization (WHO) recommended data. The composition of the complex, 1:1 Zn 2+ :SAP 2− , is supported by Job's plot, ESI‐MS and single crystal X‐Ray crystallographic structure. Intracellular Zn 2+ ion is detected in Vero Cells (African Green Monkey Kidney) by using the probe, H 2 ‐SAP , in the cell lines under fluorescence microscope. The probe has successfully been applied to recover Zn 2+ in surface water.