Premium
Total Synthesis of (+)‐Sacrolide A
Author(s) -
Thirupathi Barla,
Jena Bighnanshu K.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900192
Subject(s) - kinetic resolution , yield (engineering) , hydrolysis , total synthesis , chemistry , alcohol , stereochemistry , combinatorial chemistry , catalysis , enantioselective synthesis , organic chemistry , materials science , metallurgy
A simple and an efficient synthesis of (+)‐sacrolide A has been achieved from a known compound 10 in 12 steps with 9% overall yield. Key steps involved are Jacobsen's hydrolytic kinetic resolution, Sharpless asymmetric epoxidation, trans ‐selective hydrometallation of the propargylic alcohol, and acid‐catalyzed Kita macrolactonization.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom