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First Example of the Use of Biosourced Alkyl Levulinates as Solvents for Synthetic Chemistry: Application to the Heterogeneously Catalyzed Heck Coupling
Author(s) -
Marcel Romane,
Durillon Thibault,
Djakovitch Laurent,
Fache Fabienne,
Rataboul Franck
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900153
Subject(s) - alkyl , halide , chemistry , catalysis , aryl , heck reaction , organic chemistry , combinatorial chemistry , coupling reaction , heterogeneous catalysis
Modern organic synthesis is highly demanding for environmentally friendly biosourced solvents. In this area, alkyl levulinates, that can be obtained directly from lignocellulose, represent serious candidates. This was demonstrated for the first time in this study, using Heck C−C coupling in the presence of various heterogeneous Pd‐catalysts. In most cases quantitative conversions of aryl halides were observed within short reaction time, associated with good to high isolated yields (30‐95%). In addition to be suitable solvents for this application, alkyl levulinates can be recovered and reused, offering when associated to heterogeneous catalysts facile work‐up procedure for easy obtaining of pure products.