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Facile Synthesis of 3‐Hydroxy Oxindole by a Decarboxylative Aldol Reaction of β‐Ketoacid and Isatin in WERSA
Author(s) -
Dwivedi Kartikey Dhar,
Reddy Marri Sameer,
Kumar Nandigama Satish,
Chowhan L. Raju
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900150
Subject(s) - isatin , oxindole , aldol reaction , yield (engineering) , chemistry , organic chemistry , catalysis , materials science , metallurgy
Facile synthesis of bioactive 3‐hydroxy‐oxindole by decarboxylative aldol reaction via in‐situ generated methyl enolate of β‐ketoacid and isatin in Water Extract of Rice Straw Ash (WERSA) is described. This method provides clean, simple and useful alternative to synthesize 3‐hydroxy‐oxindole. The products were isolated in excellent yield without using column chromatography. The green chemistry matrices calculated, and it also shows green protocol used.