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A Novel and Facile Synthesis of Chroman‐4‐one Derivatives via Cascade Radical Cyclization Under Metal‐free Condition
Author(s) -
Xiao YongMei,
Liu Yang,
Mai WenPeng,
Mao Pu,
Yuan JinWei,
Yang LiangRu
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900147
Subject(s) - chemistry , cascade , radical cyclization , combinatorial chemistry , metal , reaction conditions , organic chemistry , catalysis , chromatography
A novel and facile method for the synthesis of 3‐(2‐oxo‐2‐arylethyl)chroman‐4‐ones under metal‐free conditions is described. In the presence of n Bu 4 NBr and K 2 S 2 O 8 , arylaldehydes or aliphatic aldehydes with various functional groups could react with different 2‐(allyloxy)arylaldehydes via radical process to produce chroman‐4‐one derivatives in moderate to good yields. The method features metal‐free, step‐economical manner and easily available starting materials, exhibiting its practical synthetic value in some biologically active compounds.