Regioselective Synthesis, Molecular Descriptors of (1,5‐Disubstituted 1,2,3‐Triazolyl)Coumarin/Quinolone Derivatives and Their Docking Studies against Cancer Targets | Zendy

Ansary Inul | Zendy; Roy Hiren | Zendy; Das Arijit | Zendy; Mitra Debanjan | Zendy; Bandyopadhyay Amal Kumar | Zendy

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Regioselective Synthesis, Molecular Descriptors of (1,5‐Disubstituted 1,2,3‐Triazolyl)Coumarin/Quinolone Derivatives and Their Docking Studies against Cancer Targets

Author(s) -

Ansary Inul,

Roy Hiren,

Das Arijit,

Mitra Debanjan,

Bandyopadhyay Amal Kumar

Publication year - 2019

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201900114

Subject(s) - coumarin , quinolone , regioselectivity , cycloaddition , chemistry , combinatorial chemistry , docking (animal) , click chemistry , alkyne , stereochemistry , organic chemistry , catalysis , biochemistry , medicine , nursing , antibiotics

A series of (1,5‐disubstituted 1,2,3‐triazolyl)coumarin/quinolone derivatives (tcd and tqd) have been synthesized in good to excellent yields via Ag 2 O NPs catalyzed azide‐alkyne cycloaddition reactions. We then tested the drug‐likeness of tcd and tqd by analyzing molecular descriptors. Rational drug design showed that these derivatives indeed are potential anticancer agents against tankyrases.

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