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Regioselective Synthesis, Molecular Descriptors of (1,5‐Disubstituted 1,2,3‐Triazolyl)Coumarin/Quinolone Derivatives and Their Docking Studies against Cancer Targets
Author(s) -
Ansary Inul,
Roy Hiren,
Das Arijit,
Mitra Debanjan,
Bandyopadhyay Amal Kumar
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201900114
Subject(s) - coumarin , quinolone , regioselectivity , cycloaddition , chemistry , combinatorial chemistry , docking (animal) , click chemistry , alkyne , stereochemistry , organic chemistry , catalysis , biochemistry , medicine , nursing , antibiotics
Abstract A series of (1,5‐disubstituted 1,2,3‐triazolyl)coumarin/quinolone derivatives (tcd and tqd) have been synthesized in good to excellent yields via Ag 2 O NPs catalyzed azide‐alkyne cycloaddition reactions. We then tested the drug‐likeness of tcd and tqd by analyzing molecular descriptors. Rational drug design showed that these derivatives indeed are potential anticancer agents against tankyrases.