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Structures of Complexes of Gossypol with Ferrous Sulfate Based on High‐Performance Liquid Chromatography Separation, Spectroscopic Analysis, and PM3 calculations
Author(s) -
Zhang Jian,
Ran Han,
Xiong Wei,
Yang Tianyi,
Mei Yunjun,
He Dongping,
Liu Ye,
Cheng Qunpeng,
Li Shenglan,
Song Guangsen
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803967
Subject(s) - gossypol , chemistry , methanol , aldehyde , ferrous , solvent , molecule , absorption (acoustics) , chelation , absorption spectroscopy , molar ratio , high performance liquid chromatography , inorganic chemistry , organic chemistry , catalysis , materials science , biochemistry , physics , quantum mechanics , composite material
The complexes of gossypol with Fe 2+ were prepared by using methanol as solvent in the presence of CO 2 atmosphere. The results from FT‐IR spectra analysis indicated that the aromatic aldehyde groups in gossypol molecules were entirely involved in coordination with Fe 2+ . UV‐Vis absorption spectrum of the complexes in methanol solution displays blue‐shift in comparison with that of gossypol. Five compounds from the complexes were isolated by high performance liquid chromatography. The structures of the complexes are consistent with PM3 calculations. Two compounds were formed by coordination of gossypol with Fe 2+ at 1:2 molar ratio, other three compounds were formed by chelation of gossypol with Fe 2+ at molar ratio by 1:1, 1:3, and 1:4 respectively.