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Synthesis of α‐Carbolines Using Palladium‐Catalyzed Intramolecular Amination of 3‐(2‐Chlorophenyl)‐2‐Aminopyridines
Author(s) -
Hachiya Iwao,
Shimada Satoshi,
Fukutomi Makoto,
Miura Ryoya,
Shimizu Makoto
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803948
Subject(s) - aminopyridines , intramolecular force , amination , palladium , catalysis , chemistry , organic chemistry , combinatorial chemistry
Synthesis of α‐carbolines is developed using palladium‐catalyzed intramolecular amination of 3‐(2‐chlorophenyl)‐2‐aminopyridines prepared by deprotection of 2‐iminopyridines synthesized using the conjugate addition reaction of ethyl 2‐(2‐chlorophenyl)‐2‐cyanoacetate to alkynyl imines. The palladium‐catalyzed intramolecular amination of the synthesized 2‐aminopyridines proceeded smoothly under microwave irradiation conditions to give the desired α‐carbolines in moderate to good yields.