Premium
Scandium(III) Trifluoromethanesulfonate Catalyzed Reactions of Donor‐Acceptor Cyclopropanes with 1,1‐Diarylethylenes
Author(s) -
He Yuchen,
Zhu Xiaoyan,
Hu Chen,
Hong Gang,
Wang Limin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803945
Subject(s) - scandium , cyclopropane , substituent , trifluoromethanesulfonate , chemistry , catalysis , medicinal chemistry , ring (chemistry) , lewis acids and bases , acceptor , electrophile , combinatorial chemistry , photochemistry , organic chemistry , physics , condensed matter physics
A Lewis acid‐promoted D−A cyclopropane reacting with 1,1‐diarylethylenes was developed. This reaction features mild reaction conditions, easy availability of starting materials, good functional group tolerance and high yields (up to 91%). Moreover, substituent effects on product distribution were observed. The scenario of the reaction pathway was supposed to involve the Sc(OTf) 3 ‐mediated ring‐opening 1,3‐dipole intermediate followed by the attack of 1,1‐diarylethylenes.