Premium
Scandium(III) Trifluoromethanesulfonate Catalyzed Reactions of Donor‐Acceptor Cyclopropanes with 1,1‐Diarylethylenes
Author(s) -
He Yuchen,
Zhu Xiaoyan,
Hu Chen,
Hong Gang,
Wang Limin
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803945
Subject(s) - scandium , cyclopropane , substituent , trifluoromethanesulfonate , chemistry , catalysis , medicinal chemistry , ring (chemistry) , lewis acids and bases , acceptor , electrophile , combinatorial chemistry , photochemistry , organic chemistry , physics , condensed matter physics
A Lewis acid‐promoted D−A cyclopropane reacting with 1,1‐diarylethylenes was developed. This reaction features mild reaction conditions, easy availability of starting materials, good functional group tolerance and high yields (up to 91%). Moreover, substituent effects on product distribution were observed. The scenario of the reaction pathway was supposed to involve the Sc(OTf) 3 ‐mediated ring‐opening 1,3‐dipole intermediate followed by the attack of 1,1‐diarylethylenes.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom