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V 2 O 5 ‐Catalyzed One‐Pot Multicomponent of Pyrazol Naphthoquinone as Scaffolds for Potential Bioactive Compounds: Synthesis, Structural Study and Cytotoxic Activity
Author(s) -
Vairaperumal Veeramani,
Perumal Muthuraja,
Sengodu Prakash,
Shanumuganthan Saravanakumar,
Paramasivam Manisankar
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803942
Subject(s) - hela , catalysis , trifluoromethanesulfonate , chemistry , yield (engineering) , solvent , combinatorial chemistry , naphthoquinone , ethanol , cancer cell lines , nuclear chemistry , organic chemistry , in vitro , materials science , cancer cell , cancer , biochemistry , medicine , metallurgy
In the present investigation, we have designed synthesis of a set of potential cytotoxic agents contains pyrazoyl naphthoquinone framework, from 2‐hydroxy‐1,4‐naphthaquionone, ethylacetoacetate, substituted phenylhydrazines and aromatic aldehydes in presence of different catalysts in one‐pot four component method. Various metal triflate, lewis acids and metal oxides were tested in multi‐component reaction, among them, V 2 O 5 acts as best catalyst. We have also optimized the synthetic conditions such as catalyst loading, solvents and reaction time to achieve maximum yield. It is noteworthy to mention here that the sustainable solvents like ethanol found to be suitable solvent. Further, the synthesized compounds have been employed for their in‐vitro anticancer activity against cervical cancer cell line (HeLa). Among the other compound, 5i has displayed highest activity in comparison with control drug (doxorubicin) with corresponding IC 50 equal to 2.9 μM.