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Et 3 N‐ Promoted Cascade Sp 3 C‐H Bond Functionalization of Methyl Arene with Active Methylene CompoundsUnder Solvent‐Free Condition
Author(s) -
Kumar Dhirendra,
Kumari Savita,
Gajaganti Somaiah,
Srivastava Vandana,
Singh Sundaram
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803931
Subject(s) - malononitrile , methylene , surface modification , chemistry , condensation , solvent , catalysis , condensation reaction , organic chemistry , medicinal chemistry , combinatorial chemistry , polymer chemistry , physics , thermodynamics
We herein report the Et 3 N catalyzed sp 3 C−H bond functionalization of methyl arenes with active methylene compounds under solvent‐free condition using TBHP as an oxidant. These reactions are exclusively enabled by TBHP. The methyl arenes used in this reaction are highly versatile and rapidly undergo oxidation and further condensation with malononitrile /ethylcyanoacetate. This is a metal‐free, practical, inexpensive, non‐toxic and environmentally benign method.