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Simple and Green Procedures for the Synthesis of 3,5‐Bis(alkylthio)‐1,2,4‐thiadiazoles via Oxidative Dimerization of Dithiocarbamates
Author(s) -
Halimehjani Azim Ziyaei,
Sharifi Ali,
Rahimzadeh Hossein
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803832
Subject(s) - hypervalent molecule , thiadiazoles , chemistry , yield (engineering) , alkyl , iodine , oxidative phosphorylation , combinatorial chemistry , green chemistry , aqueous medium , organic chemistry , aqueous solution , reaction mechanism , catalysis , materials science , biochemistry , metallurgy
Oxidative dimerization of S ‐alkyl dithiocarbamates with molecular iodine and oxone were applied as efficient protocols for the synthesis of 3,5‐bis(alkylthio)‐1,2,4‐thiadiazoles. Performing the reactions in green solvents, obtaining excellent yield of products under mild reaction conditions, avoiding the use of transition metals and hypervalent iodines, and using inexpensive, readily available, safe and environmentally benign oxidants are the main advantages of these protocols. In addition, the reported methods in this paper allow chemists to synthesize the title compounds both in organic and aqueous media.