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An Efficient Synthesis of Darunavir Substantially Free from Impurities: Synthesis and Characterization of Novel Impurities
Author(s) -
Rapolu Rajesh Kumar,
Areveli Srinivas,
Raju V. V. N. K. V. Prasada,
Navuluri Srinivasu,
Chavali Murthy,
Mulakayala Naveen
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803825
Subject(s) - darunavir , impurity , chemistry , dimer , benzene , furan , reagent , process (computing) , combinatorial chemistry , materials science , organic chemistry , computer science , medicine , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , family medicine , operating system
An improved and novel process for the synthesis of antiviral drug Darunavir using 4‐(1,3‐dioxoisoindolin‐2‐yl)benzene‐1‐sulphonyl chloride was described to eliminate the critical furan dimer impurity which will be formed during the process. The best reaction conditions were identified by evaluating the impurity profile and their formation during the synthesis. The optimization of the process was made to control the furan dimer impurity which was one of the critical parameters in the synthesis of darunavir. All the impurities formed during the synthesis were identified, synthesized and characterized.