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Biocompatible Non‐Toxic Porous Polymeric Materials Based on Carbonate‐ and Phthalate‐Containing Dimethacrylates
Author(s) -
Kovylin Roman S.,
Baten'kin Maxim A.,
Kulikova Tatyana I.,
Egorikhina Marfa N.,
Charikova Iri.,
Gusev Sergey A.,
Rubtsova Yu. P.,
Mlyavykh Sergey G.,
Aleynik Diana Ya.,
Chesnokov Sergei A.,
Fedushkin Igor L.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803810
Subject(s) - polymer , porosity , chemical engineering , materials science , polymerization , phthalate , grafting , polymer chemistry , composite material , engineering
Polymer monolith materials of 2 mm thickness with open interconnected pores were obtained by a visible light induced radical polymerization of carbonate‐ or phthalate containing dimethacrylate in the presence of aliphatic alcohols (60 to 70 wt %) as porogenic additives. Obtained materials absorb water easily and reveal a specific surface area of 3.1 to 21.5 m 2 g −1 and a porosity of 55–72%. According SEM data the porous monoliths consist of polymer particles (size up to 1 μm) that form 3D structures with a pore size up to 5 μm for poly(carbonatedimethacrylate) and tens of microns for phthalate‐containing polydimethacrylates. Mesenchymal stem cells from the bone marrow (MSC‐BM) of the pig were picked out and characterized. The MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) tests on polymers obtained have shown their non‐cytotoxicity. MSC‐BMs spread out well on the polymeric samples and retained their viability and typical morphology during 7 days. Adhesion and viability of MSCs on the surface of materials were detected by calcein staining. The data obtained indicate that the porous polymers derived from dimethacrylates might be promising for construction of plastics for bone grafting.