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Cobalt‐Zinc‐Diimine Multicatalysis: Enhanced syn Diastereoselectivity in the Reductive Multicomponent Coupling of Aryl Bromides, Acrylates and Aldehydes
Author(s) -
Paul Jérôme,
Xavier Tania,
Presset Marc,
Le Gall Erwan,
Léonel Eric,
Pichon Christophe,
Condon Sylvie
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803710
Subject(s) - diimine , cobalt , zinc , stereoselectivity , chemistry , catalysis , aryl , enantioselective synthesis , medicinal chemistry , reductive elimination , coupling reaction , organic chemistry , polymer chemistry , alkyl
A cobalt‐zinc‐diimine multicatalytic system for the syn ‐diastereoselective multicomponent assembly of aromatic bromides, acrylates and aromatic aldehydes under reductive conditions is described. In the presence of catalytic CoBr 2 phen and the ZnBr 2 N , N′ ‐diphenyl cyclohexyldiimine complex, β‐hydroxyesters are obtained with a significant up to 8:1 syn diastereoselectivity whereas reactions conducted without L2‐1 show negligible stereoselectivity. This preliminary study should open the way to further improvements including enantioselective catalysis of the reaction.