Premium
Mesoporous MCM‐41 Silica Supported Pyridine Nanoparticle: A Highly Efficient, Recyclable Catalyst for Expeditious Synthesis of Quinoline Derivatives through Domino Approach
Author(s) -
Mal Kajal,
Chatterjee Sauvik,
Bhaumik Asim,
Mukhopadhyay Chhanda
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803708
Subject(s) - catalysis , quinoline , pyridine , isatin , domino , cascade reaction , combinatorial chemistry , reusability , one pot synthesis , mesoporous material , mesoporous silica , materials science , moiety , chemistry , organic chemistry , computer science , software , programming language
A new facile and efficient one‐pot three component approach for the preparation of 2, 3, 4‐trisubstituted quinolines by (MCM‐41)‐pyridine catalyzed reaction of easily available substituted isatins and dialkylacetylenedicarboxylates in alcohol has been developed. The (MCM‐41)‐pyridine nanopowder catalyst has been synthesized and the catalyst has been carefully characterized by various techniques including FT‐IR, XRD, HRTEM, EDS, N 2 ‐adsorption analysis etc. The materials obtained exhibit high surface area and a narrow distribution of mesoporosity. The key features of this methodology are mild reaction conditions, operational simplicity and facile product separation, high to excellent yields, as well as simple catalyst recovery and reusability. The most exciting feature of this cascade reaction is its mechanism involving the unusual ring opening of an isatin moiety, then recyclisation, aromatization followed by esterification. The synthesized substituted quinolines are expected to be used as lead compounds for the development of new drugs.