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Recent Developments in Fluorometric and Colorimetric Chemodosimeters Targeted towards Hydrazine Sensing: Present Success and Future Possibilities
Author(s) -
Manna Saikat Kumar,
Gangopadhyay Ankita,
Maiti Kalipada,
Mondal Sanchita,
Mahapatra Ajit Kumar
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803685
Subject(s) - hydrazine (antidepressant) , chemistry , nucleophile , hydrazone , combinatorial chemistry , phthalimide , nucleophilic substitution , derivative (finance) , selectivity , nucleophilic addition , methylene , organic chemistry , catalysis , chromatography , financial economics , economics
Recently, the design, synthesis and development of chemodosimeters for hydrazine with high selectivity and sensitivity has attracted tremendous attention due to its major contributions to human health and disease including applications in various platforms. In this review, we recapitulate different strategies for the design of reaction‐based colorimetric and fluorometric probes for the detection of hydrazine and their applications in hydrazine sensing in living systems. The sensing strategies for hydrazine have been divided into six categories: (a) cleavage of the acetoxy group; (b) the nucleophilic addition‐elimination on keto ester; (c) the nucleophilic substitution‐elimination to tandem cyclization on halo‐ester; (d) the nucleophilic addition reaction to phthalimide derivative to phthalhydrazide; (e) the chemical displacement of active methylene compound to hydrazone derivative and (f) Other different approaches. Additionally, a variety of techniques have been devised here for the detection of hydrazine over other comparable ions and neutral amines.