Premium
Regioselective Synthesis of Functionalized 1,3‐Thiazine‐4‐ones via Multicomponent Click Reaction Approach
Author(s) -
Hussen Abdulkadir Shube,
Monga Aparna,
Sharma Anuj
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803634
Subject(s) - thiazine , regioselectivity , click chemistry , domino , solvent , combinatorial chemistry , catalysis , hydrazine (antidepressant) , chemistry , reaction conditions , mixing (physics) , organic chemistry , chromatography , physics , quantum mechanics
Herein, we disclose a synthetic strategy for the preparation of functionalized thiazinones under exceptionally ambient condition via domino multicomponent click reaction. The protocol utilizes readily available starting materials: phenylisothiocyanates, hydrazine monohydrate and diethyl but‐2‐ynedioate or dimethyl but‐2‐ynedioate. The reaction condition merely requires mixing of substrates at room temperature without using any catalyst and/or solvent.