Regioselective Synthesis of Functionalized 1,3‐Thiazine‐4‐ones via Multicomponent Click Reaction Approach

Herein, we disclose a synthetic strategy for the preparation of functionalized thiazinones under exceptionally ambient condition via domino multicomponent click reaction. The protocol utilizes readily available starting materials: phenylisothiocyanates, hydrazine monohydrate and diethyl but‐2‐ynedioate or dimethyl but‐2‐ynedioate. The reaction condition merely requires mixing of substrates at room temperature without using any catalyst and/or solvent.