Premium
Rapid, Simple and Efficient Microwave‐Assisted Alkylation of 6‐Acetyl‐2 H ‐Benzo[e][1, 3] Oxazine‐2, 4(3 H )‐Dione
Author(s) -
Gojiya Dinesh G.,
Vekariya Mitesh B.,
Kapupara Vimal H.,
Bhatt Tejal D.,
Kalavadiya Prakash L.,
Joshi Hitendra S.
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803607
Subject(s) - alkylation , chemistry , ammonium bromide , yield (engineering) , alkyl , proton nmr , carbon 13 nmr , bromide , ammonium , phase transfer catalyst , catalysis , organic chemistry , medicinal chemistry , nuclear chemistry , materials science , biochemistry , metallurgy , pulmonary surfactant
A simple, efficient and eco‐friendly method has been developed for the synthesis of biologically active alkyl derivatives of 6‐acetyl‐2 H ‐benzo[ e ][1,3]oxazine‐2,4(3 H )‐dione by using microwave irradiations. The N‐alkylation of 6‐acetyl‐2 H ‐benzo[ e ][1,3]oxazine‐2,4(3 H )‐dione with substituted alkyl derivatives under microwave radiations in presence of Tetra‐n‐butyl ammonium bromide as a phase transfer catalyst to give the desired products. Comparison between conventional and microwave‐assisted synthesis revealed that it reduced the reaction time, improve the yield and purity of 6‐acetyl‐3‐(substituted alkyl)‐2 H ‐benzo[ e ][1,3]oxazine‐2,4(3 H )‐diones analog molecules. All the final compounds were characterized by FT‐IR, 1 HNMR, 13 CNMR, HRMS and Mass spectroscopic analysis, also succeeded to develop and analyze the single crystal XRD of compound 4 f. The antimicrobial evaluation studies show moderate activities against used microbes.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom