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A Concise Review on Pyridocoumarin/Azacoumarin Derivatives: Synthesis and Biological Activity
Author(s) -
Patra Prasanta
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803596
Subject(s) - antifungal , antimicrobial , combinatorial chemistry , pyridine , chemistry , biological activity , pyran , antibacterial activity , organic chemistry , bacteria , biology , biochemistry , microbiology and biotechnology , in vitro , genetics
Coumarins are important due to their versatile bio‐activity. Synthesised pyridocoumarin derivatives show remarkable biological activities including antifungal, antibacterial, antitumor, antiHIV, and antimicrobial activity. The present review aims to review a vast body of literature on different synthetic methodology mainly aza‐Diels Alder reaction, metal catalyzed cyclization and multicomponent reaction and bioactivity of pyridocoumarin derivatives as published during the period from 1997 up to 2017. The synthesised compounds have been reported in literature either by construction of pyridine, pyran or of both ring starting from suitable precursors.