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Studies towards the Synthesis of Aldgamycin – M
Author(s) -
Muralikrishna Katta,
Satyanarayana Vavilapalli,
Kumar Gavireddy Chaithanya,
Yadav Jhillu Singh
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803591
Subject(s) - desymmetrization , wittig reaction , aldol reaction , ring closing metathesis , metathesis , chemistry , convergent synthesis , stereochemistry , total synthesis , closing (real estate) , salt metathesis reaction , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , polymer , polymerization , political science , law
A convergent and highly stereoselctive synthesis of macrolide framework of aldgamycin – M is described. The salient features of the synthesis are the utilization of enzymatic desymmetrization, Crimmin's non‐Evans syn aldol reaction, Wittig olefination, Yamaguchi esterification and Ring closing metathesis reaction (RCM).