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One‐pot Synthesis of 4‐Aryl‐ N H‐1,2,3‐triazoles in Presence of Fe 3 O 4 @SiO 2 @Propyl‐HMTA as a New Basic Catalyst
Author(s) -
MirzaeiMosbat Maryam ,
GhorbaniVaghei Ramin ,
Sarmast Narges
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803545
Subject(s) - hexamethylenetetramine , nitromethane , sodium azide , chemistry , aldehyde , aryl , catalysis , cycloaddition , medicinal chemistry , organic chemistry , alkyl
In this paper, hexamethylenetetramine‐functionalized magnetic Fe 3 O 4 nanoparticles (Fe 3 O 4 @SiO 2 @Propyl‐HMTA) catalyst was prepared and utilized for the synthesis of 4‐aryl‐ N H‐1,2,3‐triazole derivatives. Also, the interaction between aldehyde, nitromethane, and sodium azide was investigated within the synthesis route. Henry Reaction between the aldehyde and nitromethane created an intermediate that was immediately attacked by N 3 − . As a result of this attack, 4‐aryl‐ NH ‐1,2,3‐triazole was generated through an in situ [3 + 2] cycloaddition.