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Copper‐Catalyzed One‐Pot Synthesis of Pyrrolo[1,2‐ a ]quinoxaline Derivatives from 1‐(2‐Aminophenyl)‐pyrroles and Aldehydes
Author(s) -
Krishna Thalishetti,
Reddy Thatikonda Narendar,
Laxminarayana Eppakayala,
Kalita Dipak
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803538
Subject(s) - quinoxaline , catalysis , imine , combinatorial chemistry , chemistry , substrate (aquarium) , reaction conditions , organic chemistry , oceanography , geology
A facile and highly efficient copper‐catalyzed strategy has been developed for the synthesis of pyrrolo[1,2‐a]quinoxalines from 1‐(2‐aminophenyl)‐pyrroles and aldehydes at room temperature. This reaction proceeds via imine formation, cyclisation, and oxidation in one‐pot. This strategy provides a facile and rapid access to pyrrolo[1,2‐a]quinoxalines in good to high yields under mild conditions. This process has several advantages, such as simple reaction procedure, readily available starting materials, low catalyst loading, easy product isolation, broad substrate scope, high functional group tolerance, and gram‐scale synthesis.