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Homo‐ and Cross Coupling of C‐2 Propargyl Substituted Triterpenoic Acids: Synthesis of Novel Symmetrical and Unsymmetrical Triterpene 1,3‐Diynes
Author(s) -
Gubaidullin Rinat R.,
Khalitova Rezeda R.,
Nedopekina Darya A.,
Spivak Anna Yu.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803522
Subject(s) - triterpene , betulinic acid , oleanolic acid , chemistry , stereochemistry , ursolic acid , ring (chemistry) , organic chemistry , biology , medicine , genetics , alternative medicine , pathology , chromatography
A synthesis of the first representatives of symmetrical and unsymmetrical triterpene 1,3‐diynes in which one or two triterpene cores are linked by a diyne spacer at the C‐2 position of ring A is described. The new triterpenoids are prepared by Cu‐ and Pd‐catalyzed acetylenic homo‐ and cross coupling of accessible C‐2 propynyl derivatives of betulinic, ursolic, and oleanolic acids.