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Synergistic Catalysis of Ag(I) and Organo‐ N ‐heterocyclic Carbenes: One‐Pot Synthesis of New Anticancer Spirooxindole‐1,4‐dihydropyridines
Author(s) -
Balaboina Ramesh,
Thirukovela Narasimha Swamy,
Kankala Shravankumar,
Balasubramanian Sridhar,
Bathula Surendar Reddy,
Vadde Ravinder,
Jonnalagadda Sreekantha B,
Vasam Chandra Sekhar
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803507
Subject(s) - chemistry , malononitrile , catalysis , carbene , adduct , ammonium acetate , ethanol , medicinal chemistry , combinatorial chemistry , dihydropyridine , ammonium , organic chemistry , calcium , high performance liquid chromatography
Ag(I)/organo‐NHC catalyst pair (Lewis acidic/basic) delivered from labile Ag(I)‐NHC complex in ethanol has shown synergistic effect to catalyze the one‐pot four‐component reaction of isatins, malononitrile, cyclic ketones and ammonium acetate to produce new series of spirooxindole‐1,4‐dihydropyridine scaffolds. Carbene trapping from pre‐synthesized Ag(I)‐NHC in the form of zwitterionic CS 2 ‐NHC adduct in ethanol provides evidence for the proposed synergistic catalysis. Besides, preliminary results of anticancer activity of these new spirooxindole‐1,4‐dihydropyridines are also presented.