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A Novel Route to Substituted 2‐( N ‐Arylamino)benzothiazoles via Iron‐Promoted C‐S Bond Formation
Author(s) -
Pinapati Srinivasa rao,
Mandapati Usha rani,
Tamminana Ramana,
Rudraraju Ramesh raju
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803441
Subject(s) - substrate (aquarium) , catalysis , combinatorial chemistry , chemistry , scope (computer science) , transition metal , reaction conditions , coupling reaction , nanotechnology , medicinal chemistry , materials science , organic chemistry , computer science , oceanography , programming language , geology
Abstract The synthesis of 2‐aminobenzothiazoles has been demonstrated in the presence of transition metal under mild reaction conditions. In this paper, disubstituted thioureas have also been reported from isothiocyanates at room temperature. Subsequently, C−S cross‐coupling reaction was described for the construction of benzothiazoles using cheap, readily available and air stable Iron catalyst. Moreover, no other byproducts could be observed except target products. Furthermore, control experiments were performed for reveal the mechanism. In addition, a broad range of substrate scope has been explored.