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A Quantitative and Rapid Knoevenagel Condensation Catalyzed by Recyclable Zeolite Imidazole Frameworks
Author(s) -
Kumar Nandigama Satish,
Reddy Marri Sameer,
Kumar S. Tirumala Santosh,
Bheeram Vema Reddy,
Mukkamala Saratchandra Babu,
Rao L. Chandrasekhara
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803302
Subject(s) - knoevenagel condensation , malononitrile , catalysis , imidazole , zeolite , chemistry , condensation , gram , product (mathematics) , organic chemistry , combinatorial chemistry , mathematics , physics , thermodynamics , genetics , geometry , biology , bacteria
We here report a comparative study on catalytic application of ZIF‐8 and ZIF‐67 for the Knoevenagel condensation of diverse isatins/indeno[1,2‐b]quinoxalin‐11‐nones with malononitrile, quantitatively. Good to excellent yields of product in analytically pure form were isolated without using column chromatography. The presented method was successfully scaled up to gram scale and the catalyst was reused up to 4 successive cycles without considerable loss in its catalytic efficiency.