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Synthesis, Characterization, Anticancer and Antimicrobial Activity Studies of Novel Isomeric 2,4‐Disubstituted Ureide Derivatives of Pyrimidinopiperidines
Author(s) -
Bhavanam Lourdu Rani,
Kotra Vijay,
Mule Sivanagi Reddy,
Krishna Khandapu Bala Murali,
Bollikolla Hari Babu
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803294
Subject(s) - antimicrobial , in vitro , cancer cell lines , mtt assay , chemistry , bacteria , cytotoxicity , cell culture , combinatorial chemistry , stereochemistry , biochemistry , microbiology and biotechnology , cancer cell , cancer , biology , organic chemistry , genetics
A series of isomeric ureide derivatives of novel 2,4‐disubstituted pyrimidinopiperidines were synthesized starting from 2,4‐dichloropyrimidine. All the final products were purified on silica and characterized by spectral analysis. Both the 2,4‐disubstituted pyrimidinopiperidines were analyzed for their in vitro anticancer activity on the cell lines HCT116, MIA‐PaCa2 and MDA‐MB 231 by using MTT cell proliferation assay. Further, the antimicrobial studies were carried out against different bacterial and fungal strains by employing cup plate method. These compounds were showed significant anticancer activity on tested three cancer cell lines and exhibited potent antimicrobial activity in tested strains of bacteria and fungi.