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Five‐, Four‐ and Three‐Dentate Europium Chelates for Anion Sensing and Their Applicability to Enzymatic Dephosphorylation Reactions
Author(s) -
Mohamed Zainelabdeen. H.,
Soukka Tero,
Arenz Christoph,
Schäferling Michael
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803287
Subject(s) - europium , luminescence , chemistry , pyrophosphate , selectivity , lanthanide , chromophore , chelation , luminescent measurements , denticity , quenching (fluorescence) , photochemistry , ion , inorganic chemistry , enzyme , fluorescence , organic chemistry , materials science , catalysis , crystal structure , physics , optoelectronics , quantum mechanics
The design of anion‐sensitive probes with sufficient sensitivity and selectivity is a demanding task in analytical sciences and chemical sensor technology. The reversible binding of anions to lanthanide centers is a possible approach for the development of molecular anion sensors, as reversibility is a prerequisite for continuous sensing and monitoring of enzymatic reactions. Some anion species lead to a strong increase of luminescence intensities and lifetimes by the replacement of luminescence quenching water molecules, though the selectivity of the luminescence response is still a major problem. We synthesized a series of positively charged pyridyl‐based multidentate europium complexes (five‐, four‐ and three dentate) including sensitizing chromophores and studied their luminescence intensity and lifetime responses to different polyphosphates, pyrophosphate, phosphate anions, and carboxyanions. The results revealed that the number and symmetry of the binding sites have a significant impact on the response. The five‐dentate complex was used for the real‐time monitoring of the activity of the ATP hydrolyzing enzyme apyrase.