Premium
Enantioselective Access to Axial Biaryls via Ruthenium‐Catalyzed Hydrogen‐Transfer Reductive Amination
Author(s) -
Zhang Bei,
Liu Lala,
Guo Donghui,
Wang Jian
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803246
Subject(s) - ruthenium , amination , enantioselective synthesis , catalysis , reductive amination , transfer hydrogenation , kinetic resolution , combinatorial chemistry , chemistry , amine gas treating , organic chemistry
Axially chiral biaryls are widespread in natural products, and often utilized as chiral ligands or catalysts in asymmetric catalysis. Driven by the demand of efficient assembly of axial biaryls, we describe herein a novel atropoenantioselective synthesis of biaryls via a ruthenium catalyzed hydrogen‐transfer reductive amination and dynamic kinetic resolution process. This protocol enriches the diversity of axial biaryl amine‐alcohols bearing various substituents and functional groups.