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Silver‐Catalyzed Arylation of (Hetero)arenes via Oxidative Benzylic C−C Bond Cleavage of Benzyl Alcohols/ Benzaldehyde
Author(s) -
Mahajan Bhushan,
Aand Dnyaneshwar,
Singh Ajay K.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803215
Subject(s) - benzaldehyde , chemistry , aryl , catalysis , bond cleavage , alkylation , alkyl , benzyl alcohol , selectivity , organic chemistry , combinatorial chemistry , medicinal chemistry
Transition metal catalyzed direct cross coupling between benzyl alcohols/benzaldehyde and arenes/heteroarenes have been developed. By controlling electronic features of ancillary ligands, selectivity switch was observed between alkylated and arylated product. This newly developed protocol involves multi‐step alkyl oxidation and subsequent decarboxylative cross‐coupling to generate aryl‐aryl (C−C bond) scaffolds via radical pathways.