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Ultrasonic Methylation of Triethylammonium Thiolate as a Key Strategy for Synthesis of Tetrahydropyrazine‐Containing 2‐Oxindole Scaffold
Author(s) -
Alizadeh Abdolali,
Rezaiyehraad Reza,
Halvagar Mohammadreza
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803085
Subject(s) - ethylenediamine , oxindole , chemistry , dimethylformamide , methyl iodide , iodide , combinatorial chemistry , scaffold , ultrasonic sensor , organic chemistry , catalysis , computer science , solvent , physics , database , acoustics
This study reports an efficient synthesis of 3‐(5,6‐dihydropyrazinyliden)‐1 H ‐indol‐2‐ones via one‐pot, two step procedure between triethylammonium thiolates, methyl iodide and ethylenediamine in DMF (dimethylformamide) under ultrasound irradiation. Short reaction time and a simple procedure are among the benefits of this reaction.