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Palladium‐Catalyzed C2‐Selective Alkynylation of Indoles with Bromoalkynes
Author(s) -
Zhao Shufang,
Ma Wenchao,
Yasir Mumtaz,
Zhou Xinli,
Cheng Jintang,
Jiang Chao
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201803010
Subject(s) - alkynylation , indole test , moiety , regioselectivity , palladium , functional group , catalysis , chemistry , halide , combinatorial chemistry , stereochemistry , organic chemistry , polymer
The Pd(II) catalyzed direct C2 alkynylation of indoles bearing N ‐2‐pyrimidyl or N ‐2‐pyridinyl moiety as a site‐specific directing group was developed with alkynyl halide. A highly regioselective manner can be achieved on a range of indole substrates with excellent functional group tolerance.
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