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Design, Synthesis, Characterization and Biological Evaluation of Ruthenium Complexes of Flavonethiosemicarbazones as Antiproliferative and Mycobacterial Activities
Author(s) -
Singh Ashok K.,
Saxena Gunjan,
Singh Ravindra K.,
Kumari Lovely,
Sharma Rishabh,
Singh Sudheer K.,
Arshad Mohamad
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802929
Subject(s) - ruthenium , chemistry , stereochemistry , mtt assay , medicinal chemistry , resazurin , nuclear chemistry , cell growth , organic chemistry , catalysis , biochemistry
The ruthenium(II) complexes of 3‐hydroxy‐4'‐substituted flavonethiosemicarbazones, (where 4 '‐ substituents are ‐OCH 3 (LB1), ‐Cl (LB2), NMe 2 (LB3)) with Ru(bpy) 2 Cl 2 and Ru (phen) 2 Cl 2 (bpy=2, 2′ bipyridine; Phen=1, 10 phenanthroline) viz . [Ru(bpy) 2 (LB1)]Cl 2 (MB1), [Ru(bpy) 2 (LB2)]Cl 2 .2H 2 O, (MB2), [Ru(bpy) 2 (LB3)]Cl 2 .H 2 O (MB3), [Ru(phen) 2 (LB1)]Cl 2 .H 2 O, (MP1), [Ru(phen) 2 (LB2)]Cl 2 ⋅1.5H 2 O (MP2), [Ru(phen) 2 (LB3)]Cl 2 (MP3) were synthesized in good yield. All the compounds were characterized by elemental analysis, IR, 1 H NMR, UV/Vis spectroscopy and ESI‐MS. The spectral features of the complexes matches well to their corresponding formula. The gas phase molecular structures of all complexes were determined using density functional theory (DFT) calculations. All the compounds were screened on A549 (Human Lung carcinoma) cell line using the MTT cell viability assay. The anti‐mycobacterial drug susceptibility testing (DST) was performed using Resazurin Microtiter plate assay with glycerol as carbon source. The effect of compounds on morphological changes of cultured cells was analysed. The compound MB2 showed good cytotoxic activity against human lung carcinoma cell line A549. Similarly, compound MP2 showed good anti‐mycobacterial activity with more than 40% inhibition of growth.