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Regioselective Chlorination of Quinoline Derivatives via Fluorine Mediation in a Microfluidic Reactor
Author(s) -
Qi Hao,
Li Xin,
Liu Zhuang,
Miao ShanShan,
Fang Zheng,
Chen Lin,
Guo Kai
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802925
Subject(s) - selectfluor , quinoline , tetrafluoroborate , regioselectivity , octane , fluorine , fluoride , chemistry , derivative (finance) , combinatorial chemistry , organic chemistry , inorganic chemistry , catalysis , ionic liquid , financial economics , economics
A novel green and efficient reaction route for the synthesis of 2 ‐chloroquinoline via N ‐fluoride fluorinated by 1‐Chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo [2.2.2] octane bis(tetrafluoroborate) (Selectfluor) with 1,3 ‐Dichloro‐ 5,5 ‐dimethylhydantoin (DCDMH) in Vapourtec reactor has been developed. In addition, a series of C2 heterocyclic derivative products are obtained in moderate to good yields under no metal conditions.
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