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FeCl 3 /PVP as Green Homogeneous Catalyst to Synthesize 5‐Amino‐1 H ‐Pyrazole‐4‐Carbonitriles from Malononitrile Derivatives
Author(s) -
Elnagdy Hanan M. F.,
Sarma Diganta
Publication year - 2019
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802919
Subject(s) - malononitrile , yield (engineering) , catalysis , pyrazole , chemistry , solvent , homogeneous , ethanol , organic chemistry , nuclear chemistry , combinatorial chemistry , materials science , mathematics , composite material , combinatorics
The homogenous catalytic system “FeCl 3 /PVP” and green solvent system “water/PEG‐400” has been presented as a green pathway to synthesize 4‐amino‐1‐aryl‐1H‐pyrazole‐4‐carbonitrile and its derivatives from a series of phenyl hydrazines and malononitriles. The new approach enhanced the reaction yield of the desired product up to 97% in 2–4 h time whereas the traditional thermal method gives only 87% maximum yield in relatively longer reaction time (3‐7 h). The catalytic system has remarkable benefits such as it is inexpensive, stable, easy to prepare and very efficient with a small loading of FeCl 3 (5 mol%).