Premium
Synthesis of Isoquinoline from Benzimidates via Ru(II)‐Catalyzed C–H Alkylation/Annulations with Diazo Compounds
Author(s) -
Borah Gongutri,
Ramaiah Danaboyina,
Patel Pitambar
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802831
Subject(s) - isoquinoline , carbenoid , diazo , alkylation , chemistry , catalysis , functional group , combinatorial chemistry , medicinal chemistry , organic chemistry , rhodium , polymer
A Ru(II)‐catalyzed C–H alkylation/annulations of benzimidate with diazo compounds have been developed for the synthesis of functionalized isoquinoline. The reaction proceeds under mild condition and exhibit broad functional group tolerance. This strategy also provides a direct approach to isoquinolines and 3,4‐dihydrophenanthridin synthesis. Moreover, Ru(II)‐catalyzed C−H carbenoid functionalization of benzimidate with diazodiester is also demonstrated.