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Phosphine‐Catalyzed [3 + 2] Annulation of γ ‐ Substituted Allenoates: Novel Access to Functionalized Cyclopentenes and Bicyclic[3, 3, 0]octene Derivatives
Author(s) -
Li Erqing,
Jin Hongxing,
Huang You
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802800
Subject(s) - phosphine , annulation , bicyclic molecule , catalysis , chemistry , combinatorial chemistry , substrate (aquarium) , medicinal chemistry , organic chemistry , biology , ecology
The phosphine‐catalyzed [3 + 2] cyclizations of γ‐substituted allenoates have been applied to the synthesis of functionalized cyclopentenes and bicyclic compounds in moderate to good yields. The operation is simple and scalable with good functional group tolerance. In addition, the novel substrate‐controlled phosphine‐catalyzed domino reaction not only enriches the chemistry of γ‐substituted allenoates, but also enables easy access to skeletally diverse products.