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A New One‐Pot Synthesis of Tetrasubstituted Pyrazines by the Ti‐Catalyzed Reaction of Aromatic and Benzyl‐Substituted Nitriles with EtAlCl 2
Author(s) -
Khafizova Leila O.,
Shaibakova Mariya G.,
Dzhemilev Usein M.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201802787
Subject(s) - catalysis , chemistry , reaction conditions , combinatorial chemistry , metal , organic chemistry
A new one‐pot catalytic synthesis of tetrasubstituted pyrazines based on reaction of nitriles with EtAlCl 2 in the presence of metallic Mg and the Cp 2 TiCl 2 catalyst with good yields (60‐90%) has been developed. The probable mechanistic scheme for the formation of substituted pyrazines is proposed.